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Percées thérapeutiques en oncologie : pour de meilleurs traitements et une prise en charge améliorée
Abstract
En oncologie, les récents progrès ont considérablement transformé le traitement du cancer et la prise en charge des soins, insufflant un nouvel espoir aux patients du monde entier. La présente recension des écrits examine les grandes percées thérapeutiques que sont les thérapies ciblées, l’immunothérapie, la médecine personnalisée et les systèmes innovateurs de libération de médicaments. Ces interventions de pointe ont amélioré le devenir des patients, les taux de survie et la qualité de vie, mais elles ont aussi complexifié la prise en charge des effets secondaires, la coordination des soins et l’allocation des ressources. La présente recension des écrits aborde les répercussions de ces nouveaux traitements sur les soins aux patients, les considérations éthiques sous-jacentes, la prise en charge des effets secondaires et le rôle central des infirmières en oncologie dans l’administration et la prise en charge des traitements. Le présent article, qui explore le portrait actuel des traitements oncologiques et les voies d’avenir, comme les vaccins contre le cancer et la médecine de précision, permet une compréhension exhaustive de l’influence qu’auront ces innovations sur l’orientation future des soins oncologiques.
Mots-clés : oncologie, thérapies ciblées, immunothérapie, médecine personnalisée, systèmes de libération de médicaments
10.5737/23688076354598
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Ayala Ceja, M., Khericha, M., Harris, C. M., et al. (2024). Autologous CAR-T cell manufacturing. J Exp Med., 221(1).
Cancer.gov (2023). Transforming NCI cancer clinical trials. (2023, April 14). https://www.cancer.gov/news-events/cancer-currents-blog/2023/transforming-nci-cancer-clinical-trials
Cancer.gov (2024). Targeted therapy drug list by cancer type. (2024, July 16). https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/approved-drug-list.
Chehelgerdi, M., Chehelgerdi, M., Allela, O. Q. B., Pecho, R. D. C., Jayasankar, N., Rao, D. P., Thamaraikani, T., Vasanthan, M., Viktor, P., Lakshmaiya, N., Saadh, M. J., Amajd, A., Abo-Zaid, M. A., Castillo-Acobo, R. Y., Ismail, A. H., Amin, A. H., & Akhavan-Sigari, R. (2023). Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation. Molecular Cancer, 22(1), 169. https://doi.org/10.1186/s12943-023-01865-0
Crico, C., Sanchini, V., Casali, P. G., & Pravettoni, G. (2022). Ethical issues in oncology practice: A qualitative study of stakeholders’ experiences and expectations. BMC Medical Ethics, 23(1), 67. https://doi.org/10.1186/s12910-022-00803-x
DePeaux, K., Rivadeneira, D. B., Lontos, K., Dean, V. G., Gunn, W. G., Watson, M. J., Yao, T., Wilfahrt, D., Hinck, C., Wieteska, L., Thorne, S. H., Hinck, A. P., & Delgoffe, G. M. (2023). An oncolytic virus-delivered TGF? inhibitor overcomes the immunosuppressive tumor microenvironment. The Journal of Experimental Medicine, 220(10), e20230053. https://doi.org/10.1084/jem.20230053
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Foy, S. P., Jacoby, K., Bota, D. A., Hunter, T., Pan, Z., Stawiski, E., Ma, Y., Lu, W., Peng, S., Wang, C. L., Yuen, B., Dalmas, O., Heeringa, K., Sennino, B., Conroy, A., Bethune, M. T., Mende, I., White, W., Kukreja, M., Gunturu, S., … Mandl, S. J. (2023). Non-viral precision T cell receptor replacement for personalized cell therapy. Nature, 615(7953), 687–696. https://doi.org/10.1038/s41586-022-05531-1
Gambardella, V., Tarazona, N., Cejalvo, J. M., Lombardi, P., Huerta, M., Roselló, S., Fleitas, T., Roda, D., & Cervantes, A. (2020). Personalized medicine: Recent progress in cancer therapy. Cancers, 12(4), 1009. https://doi.org/10.3390/cancers12041009
Hantel, A., Walsh, T. P., Marron, J. M., Kehl, K. L., Sharp, R., Van Allen, E., & Abel, G. A. (2024). Perspectives of oncologists on the ethical implications of using artificial intelligence for cancer care. JAMA Network Open, 7(3), e244077. https://doi.org/10.1001/jamanetworkopen.2024.4077
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Osman, A. E. G., & Deininger, M. W. (2021). Chronic myeloid leukemia: Modern therapies, current challenges and future directions. Blood Reviews, 49, 100825. https://doi.org/10.1016/j.blre.2021.100825
Oncology Nursing Society. (2021, April 6). New guidelines in cancer care. ONS Voice. https://voice.ons.org/news-and-views/new-guidelines-in-cancer-care
Lyu, X. C., Jiang, H. J., Lee, L. H., Yang, C. I., & Sun, X. Y. (2024). Oncology nurses’ experiences of providing emotional support for cancer patients: a qualitative study. BMC Nursing, 23(1), 58. https://doi.org/10.1186/s12912-024-01718-1
National Coalition for Cancer Survivorship (2020). Quality Cancer Care. https://canceradvocacy.org/policy/quality-cancer-care/
Pancholi, N. J. (2024b, February 2). Experts forecast 2024, Part 1: Advances in cancer vaccines – American Association for Cancer Research (AACR). American Association for Cancer Research (AACR). https://www.aacr.org/blog/2024/01/08/experts-forecast-cancer-research-and-treatment-advances-in-2024-part-1/
Peng, V., Trsan, T., Sudan, R., Bhattarai, B., Cortez, V. S., Molgora, M., Vacher, J., & Colonna, M. (2024). Inositol phosphatase INPP4B sustains ILC1s and intratumoral NK cells through an AKT-driven pathway. The Journal of Experimental Medicine, 221(3), e20230124. https://doi.org/10.1084/jem.20230124
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Rulten, S. L., Grose, R. P., Gatz, S. A., Jones, J. L., & Cameron, A. J. M. (2023). The future of precision oncology. International Journal of Molecular Sciences, 24(16), 12613. https://doi.org/10.3390/ijms241612613
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Sun, C., España, S., Richarz, N., Solé-Blanch, C., Boada, A., Martinez-Cardús, A., Chu, A., Liu, Z., & Manzano, J. L. (2024). Targeted therapy or immunotherapy in BRAF-mutated metastatic melanoma: A Spanish center’s decade of experience. Frontiers in Oncology, 14. https://doi.org/10.3389/fonc.2024.1322116
Tenner, L., & Helft, P. R. (2013). Ethical challenges in oncology, explored through a series of vignettes. Oncology, 27(2), 87–90.
The University of Kansas Cancer Center (2024). New prostate cancer treatment approach slows progression. https://www.kucancercenter.org/news-room/news/2024/06/prostate-cancer-treatment-slows-progression
Unger, J. M., Cook, E., Tai, E., & Bleyer, A. (2016). The role of clinical trial participation in cancer research: Barriers, evidence, and strategies. American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, 35, 185–198. https://doi.org/10.1200/EDBK_156686
Weintraub, K. (2022, November 13). New cancer therapy takes personalized medicine to a new level. https://medicalxpress.com/news/2022-11-cancer-therapy-personalized-medicine.html
World Economic Forum. (2024). 11 new breakthroughs in the fight against cancer. https://www.weforum.org/agenda/2024/07/cancer-treatment-and-diagnosis-breakthroughs/
Yang, Q., Guo, N., Zhou, Y., Chen, J., Wei, Q., & Han, M. (2020). The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy. Acta pharmaceutica Sinica. B, 10(11), 2156–2170. https://doi.org/10.1016/j.apsb.2020.04.004
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