Utilité d’une évaluation infirmière systématique du risque de neutropénie fébrile induite par la chimiothérapie
Abstract
Les lignes directrices fondées sur les preuves recommandent que les patients à risque élevé (≥ 20 %) de neutropénie fébrile (NF) reçoivent des facteurs de croissance hématopoïétiques à titre prophylactique (Aapro et al., 2006; Koroukis et al., 2008; National Comprehensive Cancer Network [NCCN], 2008; Smith et al., 2006). Nous avons étudié l’utilité de faire effectuer par les infirmières une évaluation systématique du risque de NF chez les nouveaux patients avant le commencement de la chimiothérapie. Quinze infirmières ont utilisé un outil normalisé afin d’évaluer le risque de NF chez 150 patients. Chez 94 % des patients ainsi examinés, les infirmières ont décelé des facteurs de risque exigeant des interventions en vue de réduire l’incidence de la NF. Lors de la phase finale d’évaluation de l’outil, 67 % des infirmières ont déclaré que l’emploi d’un outil normalisé les avait aidées à identifier les patients à risque de NF, et 73 % d’entre elles projetaient d’évaluer systématiquement le risque de NF. Les infirmières trouveront que l’évaluation du risque de NF au moyen d’une liste de contrôle normalisée avant le commencement de la chimiothérapie est une procédure à la fois réalisable et fort utile.
Full Text:
PDFReferences
Aapro, M.S., Cameron, D.A., Pettengell, R., Bohlius, J., Crawford, J., Ellis,
M., et al. (2006). EORTC guidelines for the use of granulocyte-colony
stimulating factor to reduce the incidence of chemotherapyinduced
febrile neutropenia in adult patients with lymphomas and
solid tumours. European Journal of Cancer, 42(15), 2433–2453.
Bonadonna, G., Valagussa, P., Moliterni, A., Zambetti, M., & Brambilla,
C. (1995). Adjuvant cyclophosphamide, methotrexate, and
fluorouracil in node-positive breast cancer: The results of 20 years
of follow-up. New England Journal of Medicine, 332(14), 901–906.
Budman, D.R., Berry, D.A., Cirrincione, C.T., Henderson, I.C., Wood,
W.C., Weiss, R.B., et al. (1998). Dose and dose intensity as
determinants of outcome in the adjuvant treatment of breast
cancer. The Cancer and Leukemia Group B. Journal of the
National Cancer Institute, 90(16), 1205–1211.
Caggiano, V., Weiss, R.V., Rickert, T.S., & Linde-Zwirble, W.T.
(2005). Incidence, cost, and mortality of neutropenia
hospitalization associated with chemotherapy. Cancer, 103(9),
–1924.
Cordonnier, C., Herbrecht, R., Buzyn, A., Leverger, G., Leclercq, R.,
Nitenberg, G., et al. (2005). Risk factors for Gram-negative bacterial
infections in febrile neutropenia. Haematologica, 90(8),
–1109.
Dale, D.C. (2002). Colony-stimulating factors for the management of
neutropenia in cancer patients. Drugs, 62(supp 1), 1–15.
Desjardins, B., & Meilleur, M.-C. (2005). Epidemiology of febrile
neutropenia in Canadian provinces: Hospitalization-based
incidence. Presented at the 7th International Symposium on
Febrile Neutropenia, January 27–29, 2005, Seville, Spain.
Donohue, R. (2006). Development and implementation of a risk
assessment tool for chemotherapy-induced neutropenia.
Oncology Nursing Forum, 33(2), 347–352.
Doyle, A. (2006). Prechemotherapy assessment of neutropenic risk.
Oncology Nurse Edition, 20(10, Suppl. 7). Retrieved June 6, 2007,
from http://www.cancernetwork/nurses-edition
Epelbaum, R., Faraggi, D., Ben-Arie, Y., Ben-Shahar, M., Haim, N., Ron,
Y., et al. (1990). Survival of diffuse large cell lymphoma. A
multivariate analysis including dose intensity variables. Cancer,
(6), 1124–1129.
Gaytán-MartÃnez, J., Mateos-Garcia, E., Sánchez-Cortes, E., González-
Llaven, J., Casanova-Cardiel, L.J., Fuentes-Allen, J.L. (2000).
Microbiological findings in febrile neutropenia. Archives of
Medical Research, 31(4), 388–392.
Johnson, G.D., Moore, K., & Fortner, B. (2007). Baseline evaluation of
the AIM Higher Initiative: Establishing the mark from which to
measure. Oncology Nursing Forum, 34(3), 729–734.
Kouroukis, C.T., Chia, S., Verma, S., Robson, D., Desbiens, C., Cripps,
C., et al. (2008). Canadian supportive care recommendations for
the management of neutropenia in patients with cancer. Curr
Oncol, 15(1), 9–23.
Kuderer, N.M., Dale, D.C., Crawford, J., Cosler, L.E., & Lyman, G.H.
(2006). Mortality, morbidity, and cost associated with febrile
neutropenia in adult cancer patients. Cancer, 106(10),
–2266.
Kwak, L.W., Halpern, J., Olshen, R.A., & Horning, S.J. (1990).
Prognostic significance of actual dose intensity in diffuse largecell
lymphoma: Results of a tree-structured survival analysis.
Journal of Clinical Oncology, 8(6), 963–977.
Lenhart, C. (2004). Performance improvement to ensure
chemotherapy dose delivery. Oncology Supportive Care
Quarterly, 2(4), 6–14.
Lyman, G.H., Dale, D.C., & Crawford, J. (2003). Incidence and
predictors of low dose-intensity in adjuvant breast cancer
chemotherapy: A nationwide study of community practices.
Journal of Clinical Oncology, 21(24), 4524–4531.
Lyman, G.H., Dale, D.C., Friedberg, J., Crawford, J., & Fisher, R.I.
(2004). Incidence and predictors of low chemotherapy doseintensity
in aggressive non-Hodgkin’s lymphoma: A nationwide
study. Journal of Clinical Oncology, 22(21), 4302–4311.
Lyman, G.H. (2005). Guidelines of the National Comprehensive
Cancer Network on the use of myeloid growth factors with
cancer chemotherapy: A review of the evidence. Journal of the
National Comprehensive Cancer Network, 3(4), 557–571.
Lyman, G.H., Lyman, C.H., & Agboola, O. (2005). Risk models for
predicting chemotherapy-induced neutropenia. Oncologist, 10(6),
–437.
Maxwell, C., & Stein, A. (2006). Implementing evidence-based
guidelines for preventing chemotherapy-induced neutropenia:
From paper to clinical practice. Community Oncology, 3,
–536.
National Comprehensive Cancer Network. Myeloid Growth Factors:
The National Comprehensive Cancer Network Clinical Practice
Guidelines in Oncology, version 1.2008. January 2, 2008.
Retrieved August 4, 2008, from http://www.nccn.org
Smith, T.J.C., Khatcheressian, J., Lyman, G.H., Ozer, H., Armitage,
J.O., Balducci, L., et al. (2006). 2006 update of recommendations
for the use of white blood cell growth factors: An evidence-based
clinical practice guideline. Journal of Clinical Oncology, 24(19),
–3205.
Vogel, C.L., Wojtukiewicz, M.Z., Carroll, R.R., Tjulandin, S.A., Barajas-
Figueroa, L.J., Wiens, B.L., et al. (2005). First and subsequent cycle
use of pegfilgrastim prevents febrile neutropenia in patients with
breast cancer: A multicenter, double-blind, placebo-controlled
phase III study. Journal of Clinical Oncology, 23(6), 1178–1184.
White, N., Maxwell, C., Michelson, J., & Bedell, C. (2005). Protocols for
managing chemotherapy-induced neutropenia in clinical
oncology practices. Cancer Nursing, 28(1), 62–69.
Refbacks
- There are currently no refbacks.


